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Selected Publications

Secreted PGK1 and IGFBP2 contribute to the bystander effect of miR-10b gene editing in glioma.
Zhang Y, Rabinovsky R, Wei Z, El Fatimy R, Deforzh E, Luan B, Peshkin L, Uhlmann EJ, Krichevsky AM. Mol Ther Nucleic Acids. 2023

Inhibition of the epigenetically activated miR-483-5p/IGF-2 pathway results in rapid loss of meningioma tumor cell viability.
Uhlmann EJ, Mackel CE, Deforzh E, Rabinovsky R, Brastianos PK, Varma H, Vega RA, Krichevsky AM. J Neurooncol. 2023

Correction to: Tumor-Derived Cell Culture Model for the Investigation of Meningioma Biology.
Uhlmann EJ, Rabinovsky R, Varma H, El Fatimy R, Kasper EM, Moore JM, Vega RA, Thomas AJ, Alterman RL, Stippler M, Anderson MP, Uhlmann EN, Kipper FC, Krichevsky AM. J Neuropathol Exp Neurol. 2022

Tumor-Derived Cell Culture Model for the Investigation of Meningioma Biology.
Uhlmann EJ, Rabinovsky R, Varma H, El Fatimy R, Kasper EM, Moore JM, Vega RA, Thomas AJ, Alterman RL, Stippler M, Anderson MP, Uhlmann EN, Kipper FC, Krichevsky AM. J Neuropathol Exp Neurol. 2021

Promoter and enhancer RNAs regulate chromatin reorganization and activation of miR-10b/HOXD locus, and neoplastic transformation in glioma.
Deforzh E, Uhlmann EJ, Das E, Galitsyna A, Arora R, Saravanan H, Rabinovsky R, Wirawan AD, Teplyuk NM, El Fatimy R, Perumalla S, Jairam A, Wei Z, Mirny L, Krichevsky AM. Mol Cell. 2022.

Small Molecule Drugs Targeting Non-Coding RNAs as Treatments for Alzheimer’s Disease and Related Dementias.
Nguyen LD, Chau RK, Krichevsky AM.Genes (Basel). 2021

Repression of the stress granule protein G3BP2 inhibits immune checkpoint molecule PD-L1.
Zhang Y, Yue C, Krichevsky AM, Garkavtsev I. Mol Oncol. 2021

Glioblastoma-derived extracellular vesicles facilitate transformation of astrocytes via reprogramming oncogenic metabolism.
Zeng A, Wei Z, Rabinovsky R, Jun HJ, El Fatimy R, Deforzh E, Arora R, Yao Y, Yao S, Yan W, Uhlmann EJ, Charest A, You Y, Krichevsky AM. iScience. 2020

Co-cultures of Glioma Stem Cells and Primary Neurons, Astrocytes, Microglia, and Endothelial Cells for Investigation of Intercellular Communication in the Brain.
Wei Z, Kale S, El Fatimy R, Rabinovsky R, Krichevsky AM. Front Neurosci. 2019

Oligonucleotide Therapeutics as a New Class of Drugs for Malignant Brain Tumors: Targeting mRNAs, Regulatory RNAs, Mutations, Combinations, and Beyond.
Krichevsky AM, Uhlmann EJ. Neurotherapeutics. 2019

Multidimensional communication in the microenvirons of glioblastoma.
Broekman ML, Maas SLN, Abels ER, Mempel TR, Krichevsky AM, Breakefield XO. Nat Rev Neurol. 2018

MicroRNA-132 provides neuroprotection for tauopathies via multiple signaling pathways.
El Fatimy R, Li S, Chen Z, Mushannen T, Gongala S, Wei Z, Balu DT, Rabinovsky R, Cantlon A, Elkhal A, Selkoe DJ, Sonntag KC, Walsh DM, Krichevsky AM. Acta Neuropathol. 2018

Genome Editing Reveals Glioblastoma Addiction to MicroRNA-10b.
El Fatimy R, Subramanian S, Uhlmann EJ, Krichevsky AM. Mol Ther. 2017

Coding and noncoding landscape of extracellular RNA released by human glioma stem cells.
Wei Z, Batagov AO, Schinelli S, Wang J, Wang Y, El Fatimy R, Rabinovsky R, Balaj L, Chen CC, Hochberg F, Carter B, Breakefield XO, Krichevsky AM. Nat Commun. 2017

Downregulation of miR-132/212 impairs S-nitrosylation balance and induces tau phosphorylation in Alzheimer’s disease.
Wang Y, Veremeyko T, Wong AH, El Fatimy R, Wei Z, Cai W, Krichevsky AM. Neurobiol Aging. 2017

Therapeutic potential of targeting microRNA-10b in established intracranial glioblastoma: first steps toward the clinic.
Teplyuk NM, Uhlmann EJ, Gabriely G, Volfovsky N, Wang Y, Teng J, Karmali P, Marcusson E, Peter M, Mohan A, Kraytsberg Y, Cialic R, Chiocca EA, Godlewski J, Tannous B, Krichevsky AM. EMBO Mol Med. 2016

The Cancer Genome Atlas Analysis Predicts MicroRNA for Targeting Cancer Growth and Vascularization in Glioblastoma.
Wong HA, Fatimy RE, Onodera C, Wei Z, Yi M, Mohan A, Gowrisankaran S, Karmali P, Marcusson E, Wakimoto H, Stephens R, Uhlmann EJ, Song JS, Tannous B, Krichevsky AM. Mol Ther. 2015

De-repression of FOXO3a death axis by microRNA-132 and -212 causes neuronal apoptosis in Alzheimer’s disease.
Wong HK, Veremeyko T, Patel N, Lemere CA, Walsh DM, Esau C, Vanderburg C, Krichevsky AM. Hum Mol Genet. 2013

MiR-26b, upregulated in Alzheimer’s disease, activates cell cycle entry, tau-phosphorylation, and apoptosis in postmitotic neurons.
Absalon S, Kochanek DM, Raghavan V, Krichevsky AM. J Neurosci. 2013

MicroRNAs in cerebrospinal fluid identify glioblastoma and metastatic brain cancers and reflect disease activity.
Teplyuk NM, Mollenhauer B, Gabriely G, Giese A, Kim E, Smolsky M, Kim RY, Saria MG, Pastorino S, Kesari S, Krichevsky AM. Neuro Oncol. 2012

Human glioma growth is controlled by microRNA-10b.
Gabriely G, Yi M, Narayan RS, Niers JM, Wurdinger T, Imitola J, Ligon KL, Kesari S, Esau C, Stephens RM, Tannous BA, Krichevsky AM. Cancer Res. 2011

MicroRNA-124 promotes microglia quiescence and suppresses EAE by deactivating macrophages via the C/EBP-α-PU.1 pathway.
Ponomarev ED, Veremeyko T, Barteneva N, Krichevsky AM, Weiner HL. Nat Med. 2011

Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers.
Skog J, Würdinger T, van Rijn S, Meijer DH, Gainche L, Sena-Esteves M, Curry WT Jr, Carter BS, Krichevsky AM, Breakefield XO. Nat Cell Biol. 2008

miR-296 regulates growth factor receptor overexpression in angiogenic endothelial cells.
Würdinger T, Tannous BA, Saydam O, Skog J, Grau S, Soutschek J, Weissleder R, Breakefield XO, Krichevsky AM. Cancer Cell. 2008

MicroRNA 21 promotes glioma invasion by targeting matrix metalloproteinase regulators.
Gabriely G, Wurdinger T, Kesari S, Esau CC, Burchard J, Linsley PS, Krichevsky AM. Mol Cell Biol. 2008

Specific microRNAs modulate embryonic stem cell-derived neurogenesis.
Krichevsky AM, Sonntag KC, Isacson O, Kosik KS. Stem Cells. 2006

MicroRNA-21 is an antiapoptotic factor in human glioblastoma cells.
Chan JA, Krichevsky AM, Kosik KS. Cancer Res. 2005

A microRNA array reveals extensive regulation of microRNAs during brain development.
Krichevsky AM, King KS, Donahue CP, Khrapko K, Kosik KS. RNA. 2003

RNAi functions in cultured mammalian neurons.
Krichevsky AM, Kosik KS. Proc Natl Acad Sci U S A. 2002

Neuronal RNA granules: a link between RNA localization and stimulation-dependent translation.
Krichevsky AM, Kosik KS. Neuron. 2001

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